Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

First recognized as regulators of development in worms and fruitflies, microRNAs are
emerging as pivotal modulators of mammalian cardiovascular development and disease …

Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

MicroRNAs (miRNAs) are regulators of myriad cellular events, but evidence for a single
miRNA that can efficiently differentiate multipotent stem cells into a specific lineage or …

Numerous physiological and pathological stimuli promote the rearrangement of the actin
cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively …

Reprogramming of mouse fibroblasts toward a myocardial cell fate by forced expression of
cardiac transcription factors or microRNAs has recently been demonstrated. The potential …

Abstract Cardiac miRNAs (miR-1, miR133a, miR-208a/b, and miR-499) are abundantly
expressed in the myocardium. They play a central role in cardiogenesis, heart function and …

Precise regulation of the formation, maintenance, and remodeling of the vasculature is
required for normal development, tissue response to injury, and tumor progression. How …

Skeletal muscle satellite cells are adult stem cells responsible for postnatal skeletal muscle
growth and regeneration. Paired-box transcription factor Pax7 plays a central role in satellite …