Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

1. Prologue 582. The Hodgkin–Huxley formalism for computing the action potential 592.1
The axon action potential model 592.2 Cardiac action potential models 623. Ion-channel …

In this study we present a novel, robust method to couple finite element (FE) models of
cardiac mechanics to systems models of the circulation (CIRC), independent of cardiac …

This is a book about ''Simulation and Learning''. It is written for educators, teachers, and
instructional scientists, but also for instructional designers, and anyone else involved in …

Across individuals within a population, several levels of variability are observed, from the
differential expression of ion channels at the molecular level, to the various action potential …

Cardiac excitation-contraction coupling is a highly coordinated process that is controlled by
protein kinase signaling pathways, including Ca 2+/calmodulin-dependent protein kinase II …

Compartmentation and dynamics of cAMP and PKA signaling are important determinants of
specificity among cAMP's myriad cellular roles. Both cardiac inotropy and the progression of …

Cancers represent complex autonomous systems, displaying self‐sufficiency in growth
signaling. Autonomous growth is fueled by a cancer cell's ability to “secrete‐and‐sense” …

Pathological cardiac hypertrophy is a key risk factor for heart failure. It is associated with
increased interstitial fibrosis, cell death and cardiac dysfunction. The progression of …