The essential role of tick salivary glands and saliva in tick feeding and pathogen transmission

L Šimo, M Kazimirova, J Richardson… - Frontiers in cellular and …, 2017 - frontiersin.org
As long-term pool feeders, ticks have developed myriad strategies to remain discreetly but
solidly attached to their hosts for the duration of their blood meal. The critical biological …

Tick salivary compounds: their role in modulation of host defences and pathogen transmission

M Kazimírová, I Štibrániová - Frontiers in cellular and infection …, 2013 - frontiersin.org
Ticks require blood meal to complete development and reproduction. Multifunctional tick
salivary glands play a pivotal role in tick feeding and transmission of pathogens. Tick …

Ticks and tick-borne infections: complex ecology, agents, and host interactions

SK Wikel - Veterinary Sciences, 2018 - mdpi.com
Ticks transmit the most diverse array of infectious agents of any arthropod vector. Both ticks
and the microbes they transmit are recognized as significant threats to human and veterinary …

Tick saliva and its role in pathogen transmission

PA Nuttall - Wiener klinische Wochenschrift, 2019 - Springer
Tick saliva is a complex mixture of peptidic and non-peptidic molecules that aid
engorgement. The composition of tick saliva changes as feeding progresses and the tick …

The Brilliance of Borrelia: Mechanisms of Host Immune Evasion by Lyme Disease-Causing Spirochetes

C Anderson, CA Brissette - Pathogens, 2021 - mdpi.com
Lyme disease (LD) has become the most common vector-borne illness in the northern
hemisphere. The causative agent, Borrelia burgdorferi sensu lato, is capable of establishing …

Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection

AS Oliva Chávez, X Wang, L Marnin, NK Archer… - Nature …, 2021 - nature.com
Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to
humans and other animals. Here, we reveal that pathogen spreading from arthropods to the …

Tick feeding modulates the human skin immune landscape to facilitate tick-borne pathogen transmission

J Strobl, V Mündler, S Müller, A Gindl… - The Journal of …, 2022 - Am Soc Clin Investig
During cutaneous tick attachment, the feeding cavity becomes a site of transmission for tick
salivary compounds and tick-borne pathogens. However, the immunological consequences …

Tick salivary compounds for targeted immunomodulatory therapy

H Aounallah, C Bensaoud, Y M'ghirbi, F Faria… - Frontiers in …, 2020 - frontiersin.org
Immunodeficiency disorders and autoimmune diseases are common, but a lack of effective
targeted drugs and the side-effects of existing drugs have stimulated interest in finding …

The use of tick salivary proteins as novel therapeutics

J Chmelař, J Kotál, A Kovaříková… - Frontiers in physiology, 2019 - frontiersin.org
The last three decades of research into tick salivary components have revealed several
proteins with important pharmacological and immunological activities. Two primary interests …

Hard tick factors implicated in pathogen transmission

XY Liu, SI Bonnet - PLoS neglected tropical diseases, 2014 - journals.plos.org
Ticks are the most common arthropod vector, after mosquitoes, and are capable of
transmitting the greatest variety of pathogens. For both humans and animals, the worldwide …