On the basis of its generally accessible I/II redox couple and bioavailability, copper plays a
wide variety of roles in nature that mostly involve electron transfer (ET), O 2 binding …

Amine oxidases, the major enzymes of biogenic amines metabolism, are considered to be
biological regulators, especially for cell growth and differentiation. A primary involvement of …

Polyamines are important metabolites in plant development and abiotic and biotic stress
responses. Copper-containing amine oxidases (CuAOs) are involved in the regulation of …

The reduction of dioxygen is a key step in many important biological processes including
respiration and ligand oxidation. Enzymes containing either iron or copper or, indeed, both …

Owing to their chemical reactivity, radicals have cytocidal properties. Destruction of cells by
irradiation-induced radical formation is one of the most frequent interventions in cancer …

The localization of dioxygen sites in oxygen-binding proteins is a nontrivial experimental
task and is often suggested through indirect methods such as using xenon or halide anions …

Articular cartilage remains among the most difficult tissues to regenerate due to its poor self-
repair capacity. The lysyl oxidase family (LOX; also termed as protein-lysine 6-oxidase) …

The accessibility of large substrates to buried enzymatic active sites is dependent upon the
utilization of proteinaceous channels. The necessity of these channels in the case of small …

Conspectus Copper-containing amine oxidases (CuAOs) use both copper and 2, 4, 5-
trihydroxyphenylalanine quinone (TPQ) to catalyze the oxidative deamination of primary …

Semicarbazide-sensitive amine oxidase (SSAO) belongs to a ubiquitous family of copper-
containing amine oxidases (CuAOs). SSAO is also known as vascular adhesion protein-1 …