HIV and cardiovascular disease: the role of inflammation

S Dirajlal-Fargo, N Funderburg - Current Opinion in HIV and AIDS, 2022 - journals.lww.com
Mechanistic studies into the drivers of chronic inflammation in PWH are ongoing and may
aid in tailoring effective therapeutic strategies that can reduce ASCVD risk in this population …

Dyslipidemia in Human Immunodeficiency Virus Disease: JACC Review Topic of the Week

DK Kalra, M Vorla, ED Michos, A Agarwala… - Journal of the American …, 2023 - jacc.org
The advent of newer and better tolerated antiretroviral therapy has progressively shortened
the life expectancy gap between people living with HIV (PWH) and the general population …

Interleukin 6 blockade with tocilizumab diminishes indices of inflammation that are linked to mortality in treated human immunodeficiency virus infection

NT Funderburg, CL Shive, Z Chen… - Clinical Infectious …, 2023 - academic.oup.com
Background People with human immunodeficiency virus (PWH) are at increased risk for
comorbidities, and plasma interleukin 6 (IL-6) levels are among the most robust predictors of …

Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: a model for studying …

ER Bowman, CM Cameron, B Richardson… - PLoS …, 2020 - journals.plos.org
People with HIV (PWH) are at increased risk for atherosclerotic cardiovascular disease
(ASCVD). Proportions of vascular homing monocytes are enriched in PWH; however, little is …

Altered gut microbiota and host metabolite profiles in women with human immunodeficiency virus

Z Wang, M Usyk, CC Sollecito, Y Qiu… - Clinical Infectious …, 2020 - academic.oup.com
Background Alterations in gut microbiota (GMB) and host metabolites have been noted in
individuals with HIV. However, it remains unclear whether alterations in GMB and related …

Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention

J Dalli, D Kitch, MP O'Brien, PW Hunt, N Funderburg… - …, 2023 - thelancet.com
Summary Background Persons with HIV (PWH) have an increased risk of cardiovascular
disease (CVD) compared to HIV-seronegative individuals (SN). Inflammation contributes to …

Altered lipidome composition is related to markers of monocyte and immune activation in antiretroviral therapy treated human immunodeficiency virus (HIV) infection …

ER Bowman, M Kulkarni, J Gabriel, MJ Cichon… - Frontiers in …, 2019 - frontiersin.org
Background: HIV infection and antiretroviral therapy (ART) have both been linked to
dyslipidemia and increased cardiovascular disease (CVD) risk. Alterations in the …

Probing the Interface of HIV and Inflammaging

SF Sieg, CL Shive, S Panigrahi, ML Freeman - Current HIV/Aids Reports, 2021 - Springer
Abstract Purpose of Review Systemic inflammation increases as a consequence of aging
(inflammaging) and contributes to age-related morbidities. Inflammation in people living with …

HIV-1 impact on malaria transmission: a complex and relevant global health concern

A Roberds, E Ferraro, S Luckhart… - Frontiers in Cellular and …, 2021 - frontiersin.org
Malaria/HIV-1 co-infection has become a significant public health problem in the tropics
where there is geographical overlap of the two diseases. It is well described that co-infection …

Lipidome abnormalities and cardiovascular disease risk in HIV infection

E Bowman, NT Funderburg - Current HIV/AIDS Reports, 2019 - Springer
Abstract Purpose of Review Human immunodeficiency virus (HIV) infection and its treatment
with antiretroviral therapy (ART) are associated with lipid abnormalities that may enhance …