Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

While the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated …

Post-translational modifications of p53 are critical in modulating its tumor suppressive
functions. Ubiquitylation, for example, plays a major role in dictating p53 stability, subcellular …

Adenoid cystic carcinomas (ACCs) are among the most enigmatic of human malignancies.
These aggressive salivary gland cancers frequently recur and metastasize despite definitive …

CpG island hypermethylation and global genomic hypomethylation are common epigenetic
features of cancer cells. Less attention has been focused on histone modifications in cancer …

PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2
family member and a critical mediator of p53-dependent and-independent apoptosis …

In tumors that retain wild-type p53, its tumor-suppressor function is often impaired as a result
of the deregulation of HDM-2, which binds to p53 and targets it for proteasomal degradation …

Hundreds of chromatin regulators (CRs) control chromatin structure and function by
catalyzing and binding histone modifications, yet the rules governing these key processes …

Summary Lysine 2-hydroxyisobutyrylation (Khib) is an evolutionarily conserved and
widespread histone mark like lysine acetylation (Kac). Here we report that p300 functions as …