Diabetes insipidus is a disorder characterized by excretion of large amounts of hypotonic
urine. Four entities have to be differentiated: central diabetes insipidus resulting from a …

Diabetes insipidus is one of the main causes of the polyuria polydipsia syndrome and is
characterized by a high hypotonic urinary output of more than 50 mL/kg body weight per 24 …

Background The indirect water-deprivation test is the current reference standard for the
diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and …

Background Differential diagnosis of diabetes insipidus is challenging. The most reliable
approach is hypertonic saline-stimulated copeptin measurements. However, this test is …

Arginine vasopressin deficiency (AVP-D) is one of the main entities of the polyuria-
polydipsia syndrome. Its correct diagnosis and differentiation from the other two causes-AVP …

Copeptin is secreted in an equimolar amount to arginine vasopressin (AVP) but can easily
be measured in plasma or serum with a sandwich immunoassay. The main stimuli for …

Copeptin derives from the same precursor peptide preprovasopressin as arginine
vasopressin (AVP). The secretion of both peptides is stimulated by similar physiological …

Background The differential diagnosis of diabetes insipidus is challenging. The most reliable
approaches are copeptin measurements after hypertonic saline infusion or arginine, which …

Copeptin, a marker of arginine vasopressin (AVP) secretion, is elevated throughout human
pregnancies complicated by preeclampsia (PE), and AVP infusion throughout gestation is …

The two main differential diagnoses of central diabetes insipidus are nephrogenic diabetes
insipidus and primary polydipsia. Reliable distinction between those entities is essential as …