Microbial production of advanced biofuels

J Keasling, H Garcia Martin, TS Lee… - Nature Reviews …, 2021 - nature.com
Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …

The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology

TE Sandberg, MJ Salazar, LL Weng, BO Palsson… - Metabolic …, 2019 - Elsevier
Harnessing the process of natural selection to obtain and understand new microbial
phenotypes has become increasingly possible due to advances in culturing techniques …

Spatiotemporal microbial evolution on antibiotic landscapes

M Baym, TD Lieberman, ED Kelsic, R Chait, R Gross… - Science, 2016 - science.org
A key aspect of bacterial survival is the ability to evolve while migrating across spatially
varying environmental challenges. Laboratory experiments, however, often study evolution …

Adaptive laboratory evolution–principles and applications for biotechnology

M Dragosits, D Mattanovich - Microbial cell factories, 2013 - Springer
Adaptive laboratory evolution is a frequent method in biological studies to gain insights into
the basic mechanisms of molecular evolution and adaptive changes that accumulate in …

Genome dynamics during experimental evolution

JE Barrick, RE Lenski - Nature Reviews Genetics, 2013 - nature.com
Evolutionary changes in organismal traits may occur either gradually or suddenly. However,
until recently, there has been little direct information about how phenotypic changes are …

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

A Folkesson, L Jelsbak, L Yang, HK Johansen… - Nature Reviews …, 2012 - nature.com
The airways of patients with cystic fibrosis (CF) are nearly always infected with many
different microorganisms. This environment offers warm, humid and nutrient-rich conditions …

Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries

KK Hong, J Nielsen - Cellular and Molecular Life Sciences, 2012 - Springer
Metabolic engineering is the enabling science of development of efficient cell factories for
the production of fuels, chemicals, pharmaceuticals, and food ingredients through microbial …

Genome‐scale engineering for systems and synthetic biology

KM Esvelt, HH Wang - Molecular systems biology, 2013 - embopress.org
Genome‐modification technologies enable the rational engineering and perturbation of
biological systems. Historically, these methods have been limited to gene insertions or …

Rapid evolution of silver nanoparticle resistance in Escherichia coli

JL Graves Jr, M Tajkarimi, Q Cunningham… - Frontiers in …, 2015 - frontiersin.org
The recent exponential increase in the use of engineered nanoparticles (eNPs) means both
greater intentional and unintentional exposure of eNPs to microbes. Intentional use includes …

Prediction of antibiotic resistance by gene expression profiles

S Suzuki, T Horinouchi, C Furusawa - Nature communications, 2014 - nature.com
Although many mutations contributing to antibiotic resistance have been identified, the
relationship between the mutations and the related phenotypic changes responsible for the …