Cardiac safety assessment is challenging because a better understanding of torsadogenic
mechanisms beyond hERG blockade and QT interval prolongation is necessary for patient …

In the past few years, the use of specific cell types derived from induced pluripotent stem
cells (iPSCs) has developed into a powerful approach to investigate the cellular …

In the present research we tackled the classification of seven genetic cardiac diseases and
control subjects by using an extensive set of machine learning algorithms with their …

Despite major efforts by clinicians and researchers, cardiac arrhythmia remains a leading
cause of morbidity and mortality in the world. Experimental work has relied on combining …

Early afterdepolarizations (EADs) are pathological voltage fluctuations that can occur in
cardiac cells and are a potent source of potentially fatal arrhythmias. Recent works …

The pumping of blood through the heart is due to a wave of muscle contractions that are in
turn due to a wave of electrical activity initiated at the sinoatrial node. At the cellular level …

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) offer a unique in
vitro platform to study cardiac diseases, as they recapitulate many disease phenotypes. The …

Early afterdepolarizations (EADs) are voltage oscillations that can occur during the plateau
phase of a cardiac action potential. EADs at the cellular level have been linked to potentially …

The rapid dissemination of SARS-CoV-2 has made COVID-19 a tremendous social,
economic, and health burden. Despite the efforts to understand the virus and treat the …

In this article, we consider data complexity in the context of calcium transient signal data
collected from induced pluripotent stem cell‐derived cardiomyocytes. We present a novel …