Alzheimer disease (AD) is the most common contributor to dementia in the world, but
strategies that slow or prevent its clinical progression have largely remained elusive, until …

Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …

Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

Several genetic risk factors for Alzheimer's disease implicate genes involved in lipid
metabolism and many of these lipid genes are highly expressed in glial cells. However, the …

Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …

Gene and protein set enrichment analysis is a critical step in the analysis of data collected
from omics experiments. Enrichr is a popular gene set enrichment analysis web-server …

Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …

The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …

Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disease
typically characterized by memory loss, personality changes, and a decline in overall …

The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …