Pathophysiological effects of autoantibodies in autoimmune encephalitides

M Ryding, AW Mikkelsen, MS Nissen, AC Nilsson… - Cells, 2023 - mdpi.com
The heterogeneity of autoantibody targets in autoimmune encephalitides presents a
challenge for understanding cellular and humoral pathophysiology, and the development of …

Novelties in autoimmune and paraneoplastic cerebellar ataxias: twenty years of progresses

S Muniz-Castrillo, A Vogrig, NL Ciano-Petersen… - The Cerebellum, 2022 - Springer
Major advances in our knowledge concerning autoimmune and paraneoplastic cerebellar
ataxias have occurred in the last 20 years. The discovery of several neural antibodies …

Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis

H Wang, C Xie, B Deng, J Ding, N Li, Z Kou… - Nature structural & …, 2024 - nature.com
Antibodies against N-methyl-d-aspartate receptors (NMDARs) are most frequently detected
in persons with autoimmune encephalitis (AE) and used as diagnostic biomarkers …

Patients' IgLON5 autoantibodies interfere with IgLON5-protein interactions

J Landa, AB Serafim, C Gaig, A Saiz… - Frontiers in …, 2023 - frontiersin.org
Background Anti-IgLON5 disease is a rare neurological disorder characterized by
autoantibodies against IgLON5, and pathological evidence of neurodegeneration. IgLON5 is …

Rare antibody-mediated and seronegative autoimmune encephalitis: an update

N Seery, H Butzkueven, TJ O'Brien, M Monif - Autoimmunity Reviews, 2022 - Elsevier
Paralleling advances with respect to more common antibody-mediated encephalitides, such
as anti-N-methyl-D-aspartate receptor (NMDAR) and anti-leucine-rich glioma-inactivated 1 …

Immunotherapy in autoimmune encephalitis

BP Trewin, I Freeman, S Ramanathan… - Current Opinion in …, 2022 - journals.lww.com
Early first-line immunotherapies, including corticosteroids and plasma exchange, improve
outcomes, with emerging evidence showing second-line immunotherapies (especially …

Neuronal surface antigen-specific immunostaining pattern on a rat brain immunohistochemistry in autoimmune encephalitis

N Nagata, N Kanazawa, T Mitsuhata, M Iizuka… - Frontiers in …, 2023 - frontiersin.org
A variety of neuronal surface (NS) antibodies (NS-Ab) have been identified in autoimmune
encephalitis (AE). Tissue-based assay (TBA) using a rodent brain immunohistochemistry …

Differential diagnosis and comparison of diagnostic algorithms in children and adolescents with autoimmune encephalitis in Spain: a prospective cohort study and …

G Olivé-Cirera, E Fonseca, LW Chen, A Fetta… - The Lancet …, 2025 - thelancet.com
Background The usefulness of current diagnostic approaches in children with suspected
autoimmune encephalitis is unknown. We aimed to assess the diagnosis of autoimmune …

General features, pathogenesis, and laboratory diagnostics of autoimmune encephalitis

S Masciocchi, P Businaro, S Scaranzin… - Critical Reviews in …, 2024 - Taylor & Francis
Autoimmune encephalitis (AE) is a group of inflammatory conditions that can associate with
the presence of antibodies directed to neuronal intracellular, or cell surface antigens. These …

A retrospective study of autoimmune cerebellar ataxia over a 20-year period in a single institution

A Kudo, H Yaguchi, K Tanaka, A Kimura, I Yabe - Journal of Neurology, 2024 - Springer
Background It is important to differentiate autoimmune cerebellar ataxia (ACA) from
neurodegenerative CA, but this is sometimes difficult. We performed a retrospective study in …