Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …

The epidermis forms a barrier that defends the body from desiccation and entry of harmful
substances, while also sensing and integrating environmental signals. The tightly …

The widespread occurrence of microplastics (MPLs) and nanoplastics (NPLs), collectively
abbreviated as M/NPLs, has markedly affected the ecosystem and has become a global …

The epidermis is a living, multilayered barrier with five functional levels, including a physical,
a chemical, a microbial, a neuronal, and an immune level. Altogether, this complex organ …

Although, drugs are required in the various skin compartments such as viable epidermis,
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …

The skin is a unique immune organ that constitutes a complex network of physical, chemical
and microbiological barriers against external insults. Keratinocytes are the most abundant …

Background Although atopic dermatitis (AD) often starts in early childhood, detailed tissue
profiling of early-onset AD in children is lacking, hindering therapeutic development for this …

The skin protects our body from external assaults like pathogens, xenobiotics or UV
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …

Recreating the structure of human tissues in the laboratory is valuable for fundamental
research, testing interventions, and reducing the use of animals. Critical to the use of such …