Integration of viral DNA into the host genome is a central event in the replication cycle and
the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are …

HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore
compartment in CD4+ T cells. However, the genomic features of these genes and the …

Background Lentiviral vectors have emerged as efficient vehicles for transgene delivery in
both dividing and non-dividing cells. A number of different modifications in vector design …

The susceptibility of CD4 T cells to human immunodeficiency virus 1 (HIV-1) infection is
regulated by glucose and glutamine metabolism, but the relative contributions of these …

HIV-1 is transmitted between T cells through the release of cell-free particles and through
cell-cell contact. Cell-to-cell transmission is more efficient than cell-free virus transmission …

Feline immunodeficiency virus (FIV) is a naturally occurring lentivirus of domestic and
nondomestic feline species. Infection in domestic cats leads to immune dysfunction via …

HIV integrates into the host genome to create a persistent viral reservoir. Stimulation of
CD4+ memory T lymphocytes with common γc-chain cytokines renders these cells more …

Background The HIV-1 infection is characterized by profound CD4+ T cell destruction and a
marked Th17 dysfunction at the mucosal level. Viral suppressive antiretroviral therapy …

The aryl hydrocarbon receptor (AhR) regulates Th17-polarized CD4+ T cell functions, but its
role in HIV-1 replication/outgrowth remains unknown. Genetic (CRISPR-Cas9) and …

Integration is a central event in the replication of retroviruses, yet≥ 90% of HIV-1 reverse
transcripts fail to integrate, resulting in accumulation of unintegrated viral DNA in cells …