Tissue engineering scaffolds have emerged as a powerful tool within regenerative medicine.
These materials are being designed to create environments that promote regeneration …

An increasing number of therapies for spinal cord injury (SCI) are emerging from the
laboratory and seeking translation into human clinical trials. Many of these are administered …

The loss of neurons and degeneration of axons after spinal cord injury result in the loss of
sensory and motor functions. A bridging biomaterial construct that allows the axons to grow …

The immune response that accompanies spinal cord injury contributes to both injury and
reparative processes. It is this duality that is the focus of this review. Here, we consider the …

MicroRNAs are a class of small RNAs that regulate the expression of target mRNAs by
inhibiting translation or destabilizing target mRNAs. miR-126 is a microRNA that is highly …

Spinal cord injury affects more than 2.5 million people worldwide and can lead to paraplegia
and quadriplegia. Anatomical discontinuity in the spinal cord results in disruption of the …

Spinal cord injury (SCI) triggers a robust inflammatory response that contributes in part to the
secondary degeneration of spared tissue. Here, we use flow cytometry to quantify the …

Blood vessel loss and inflammation cause secondary degeneration following spinal cord
injury. Angiopoietin-1 through the Tie2 receptor, and other ligands through αvβ3 integrin …

Historically, the immune response after spinal cord injury was considered largely detrimental
owing to the release of neurotoxic factors. While there is validity to this view, there is much …

Object Oxidative stress leading to lipid peroxidation is a major cause of secondary injury
following spinal cord injury (SCI). The objectives of this study were to determine the duration …