Background Streptococcus pneumoniae is a leading cause of bacterial pneumonia,
meningitis, and sepsis in children worldwide. However, many countries lack national …

The epidemiology of bacterial meningitis has changed as a result of the widespread use of
conjugate vaccines and preventive antimicrobial treatment of pregnant women. Given the …

Streptococcus pneumoniae is a significant cause of otitis media, pneumonia, and meningitis.
Only seven of the approximately 100 serotypes were initially included in the pneumococcal …

In recent years, intense research efforts have been dedicated to elucidating the pathogenic
mechanisms of HIV-associated disease progression. In addition to the progressive depletion …

SUMMARY On February 24, 2010, a 13-valent pneumococcal polysaccharide-protein
conjugate vaccine (PCV13 [Prevnar 13, Wyeth Pharmaceuticals Inc., marketed by Pfizer …

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia,
meningitis, and bacteremia in children and adults. Invasive pneumococcal disease (IPD) …

The global burden of disease due to Streptococcus pneumoniae remains high. The licensed
7-valent pneumococcal conjugate vaccine (7vCRM, Prevenar™/Prevnar™) has successfully …

HIV disease is associated with abnormalities in all major lymphocyte populations, including
B cells. Aberrancies in the B-cell compartment can be divided into 3 broad categories …

Introduction Globally, pneumonia is the leading cause of death in children under the age of
5 years. In Kenya, it is the second leading cause of mortality, accounting for greater than …

In the combined antiretroviral therapy era, HIV-infected patients remain a vulnerable
population for the onset of bloodstream infections (BSI). Worldwide, nontyphoid …