Objective To understand the role of the genetic changes and bone marrow
microenvironment on the development, progression, and staging of multiple myeloma (MM) …

Over the past 4 decades, basic research has provided crucial information regarding the
cellular and molecular biology of cancer. In particular, the relevance of cancer …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell
population with the ability to suppress immune responses. MDSCs have been characterized …

Multiple myeloma (MM) pathogenesis and progression largely rely on the cells and
extracellular factors in the bone marrow (BM) microenvironment. Compelling studies have …

Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal
and haematopoietic cells regulate their function. The steady state HSC niche has been …

Myeloid-derived suppressor cells (MDSCs) are newly identified immature myeloid cells that
are characterized by the ability to suppress immune responses and expand during cancer …

Natural Killer (NK) cells yield promise in therapy of hematologic malignancies. The clinical
experience with adoptively transferred allogeneic NK cells over past two decades has …

Myeloid-derived suppressor cells (MDSC) are one of the major factors limiting the immune
response in cancer. However, their role in bone marrow (BM), the site of primary localization …

Exosomes, extracellular nanovesicles secreted by various cell types, modulate the bone
marrow (BM) microenvironment by regulating angiogenesis, cytokine release, immune …

The development and effectiveness of novel therapies in multiple myeloma have been
established in large clinical trials. However, multiple myeloma remains an incurable …