As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …

Introduction Sepsis-associated encephalopathy (SAE) and septic encephalitis (SE) are
associated with increased mortality, long-term cognitive impairment, and focal neurological …

Sepsis-associated encephalopathy (SAE) is a common complication of severe sepsis. Irisin
is a novel exercise-induced myokine involved in the regulation of adipose browning and …

Cardiac dysfunction resulting from sepsis may cause significant morbidity and mortality, and
ferroptosis plays a role in this pathology. Dexmedetomidine (Dex), a α2‑adrenergic receptor …

Intracerebral hemorrhage (ICH) is a highly fatal disease with mortality rate of approximately
50%. Oxidative stress (OS) is a prominent cause of brain injury in ICH. Important sources of …

Cognitive decline covers a broad spectrum of disorders, not only resulting from brain
diseases but also from systemic diseases, which seriously influence the quality of life and …

Sepsis is a systemic inflammatory disease resulting from an infection. This disorder affects
750 000 people annually in the United States and has a 62% rehospitalization rate. Septic …

Statins are a class of widely prescribed drugs used to reduce low-density lipoprotein
cholesterol (LDL-C) and important to prevent cardiovascular diseases (CVD). Most statin …

Sepsis survivors present long-term cognitive deficits. The present study was to investigate
the effect of early administration of high-dose vitamin C on cognitive function in septic rats …

Sepsis is a condition of severe organ failure caused by the maladaptive response of the host
to an infection. It is a severe complication affecting critically ill patients, which can progress …