The outbreak of Coronavirus disease 2019 (COVID-19) has evolved into an emergent global
pandemic. Many drugs without established efficacy are being used to treat COVID-19 …

The uridine diphosphate glucuronosyltransferase (UGT) enzymes are a superfamily of
enzymes responsible for the glucuronidation of target substrates. The transfer of glucuronic …

The antiretroviral protease inhibitor atazanavir inhibits hepatic uridine diphosphate
glucuronosyltransferase (UGT) 1A1, thereby preventing the glucuronidation and elimination …

Provides a timely update to a key textbook on human drug metabolism The third edition of
this comprehensive book covers basic concepts of teaching drug metabolism, starting from …

The COVID-19 pandemic is associated with a global health crisis and the greatest challenge
for scientists and doctors. The virus causes severe acute respiratory syndrome with an …

We searched PubMed entries and the Lattes database of Brazilian Pharmacogenetics
Network investigators, for pharmacogenetic/genomic (PGx) studies in the Brazilian …

Objective This study evaluated the impact of seven single nucleotide polymorphisms in five
candidate genes (ABCB1, ABCC2, ABCC4, SLC22A6, and SLC22A11) in relation to …

In nearly 40 years since human immunodeficiency virus (HIV) first emerged, much has
changed. Our understanding of the pathogenesis of HIV infection and its effect on the cells …

Lung cancer is one of the most frequent neoplasms in the world. Because it is a complex
disease, its formation occurs in several stages, stemming from interactions between …

After the introduction of highly active antiretroviral therapy in the 1990s, the perception of the
diagnosis of HIV infection gradually shifted from a 'death sentence'to a chronic disease …