Context.—Controversies and uncertainty persist in prostate cancer grading. Objective.—To
update grading recommendations. Data Sources.—Critical review of the literature along with …

Various preclinical models have been developed to clarify the pathophysiology of prostate
cancer (PCa). Traditional PCa cell lines from clinical metastatic lesions, as exemplified by …

Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish
a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Background The intractability of castration-resistant prostate cancer (CRPC) is exacerbated
by tumour heterogeneity, including diverse alterations to the androgen receptor (AR) axis …

Intraductal carcinoma of the prostate (IDC-P) is a lethal prostate cancer subtype that
generally coexists with invasive high-grade prostate acinar adenocarcinoma (PAC) but …

Fibroblast growth factors (FGFs) are a family of proteins possessing paracrine, autocrine, or
endocrine functions in a variety of biological processes, including embryonic development …

A key challenge in the management of localized prostate cancer is the identification of men
with a high likelihood of progression to an advanced, incurable stage. Patients who harbour …

Objectives To investigate the genetic alterations of patients with prostate cancer (PCa) with
and without intraductal carcinoma of the prostate (IDC‐P). Patients and Methods We …

Background Prostate cancer (PC) is the most frequently diagnosed cancer in North
American men. Pathologists are in critical need of accurate biomarkers to characterize PC …