PECAM-1: regulator of endothelial junctional integrity

JR Privratsky, PJ Newman - Cell and tissue research, 2014 - Springer
PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprising
six extracellular immunoglobulin (Ig)-like homology domains, a short transmembrane …

[PDF][PDF] The biology of PECAM-1.

PJ Newman - The Journal of clinical investigation, 1997 - Am Soc Clin Investig
Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kD member of the
immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets …

Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology

PJ Newman, DK Newman - Arteriosclerosis, thrombosis, and …, 2003 - Am Heart Assoc
Recent studies of platelet endothelial cell adhesion molecule-1 (PECAM-1 [CD31])-deficient
mice have revealed that this molecule plays an important role in controlling the activation …

Directed evolution of proteins by exon shuffling

JA Kolkman, WPC Stemmer - Nature biotechnology, 2001 - nature.com
Evolution of eukaryotes is mediated by sexual recombination of parental genomes.
Crossovers occur in random, but homologous, positions at a frequency that depends on …

CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium.

L Piali, P Hammel, C Uherek, F Bachmann… - The Journal of cell …, 1995 - rupress.org
To protect the body efficiently from infectious organisms, leukocytes circulate as
nonadherent cells in the blood and lymph, and migrate as adherent cells into tissues …

PECAM-1: conflicts of interest in inflammation

JR Privratsky, DK Newman, PJ Newman - Life sciences, 2010 - Elsevier
Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and
signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is …

Switched at birth: a new family for PECAM-1

PJ Newman - The Journal of clinical investigation, 1999 - Am Soc Clin Investig
ITIMs are identifiable by the consensus sequence L/I/V/S–x–Y–x–x–L/V and have been
found to exist alone or in pairs within the cytoplasmic domain of an increasingly recognized …

CD31 as a therapeutic target in atherosclerosis

G Caligiuri - Circulation Research, 2020 - Am Heart Assoc
The potential of CD31 as a therapeutic target in atherosclerosis has been considered ever
since its cloning in the 1990s, but the exact role played by this molecule in the biologic …

[HTML][HTML] The unfolding tale of PECAM-1

DE Jackson - FEBS letters, 2003 - Elsevier
Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is a member of the
immunoglobulin (Ig) superfamily that has distinctive features of an immunoreceptor based …

The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet …

DE Jackson, CM Ward, R Wang, PJ Newman - Journal of Biological …, 1997 - ASBMB
Platelet/endothelial cell adhesion molecule-1 (PECAM-1) is a homophilic adhesion receptor
that mediates leukocyte/endothelial cell interactions that take place during transendothelial …