White adipose tissue (WAT) is perhaps the most plastic organ in the body, capable of
regeneration following surgical removal and massive expansion or contraction in response …

Insulin signalling is uniquely required for storing energy as fat in humans. While de novo
synthesis of fatty acids and triacylglycerol occurs mostly in liver, adipose tissue is the primary …

Clinical interest in de novo lipogenesis has been sparked by recent studies in rodents
demonstrating that de novo lipogenesis specifically in white adipose tissue produces the …

Background Insulin resistance not only occurs in obesity, but also in lipodystrophy. Although
adipose tissue mass affects metabolic fluxes and participates in interorgan crosstalk, the role …

The relationship between obesity and other metabolic diseases have been deeply studied.
However, there are clinical inconsistencies, exceptions to the paradigm of “more fat means …

OBJECTIVE Regional differences among adipose depots in capacities for fatty acid storage,
susceptibility to hypoxia, and inflammation likely contribute to complications of obesity. We …

Mutations of clock genes can lead to diabetes and obesity. REV‐ERBα, a nuclear receptor
involved in the circadian clockwork, has been shown to control lipid metabolism. To gain …

The ability to maintain and expand the pool of adipocytes in adults is integral to the
regulation of energy balance, tissue/stem cell homeostasis, and disease pathogenesis. For …

BACKGROUND Epicardial adipose tissue (EAT) directly overlies the myocardium, with
changes in its morphology and volume associated with myriad cardiovascular and metabolic …

Emerging evidence reveals that adipose tissue-associated inflammation is a main
mechanism whereby obesity promotes colorectal cancer risk and progression. Increased …