Recent advances in aptamer discovery and applications

Y Zhang, BS Lai, M Juhas - Molecules, 2019 - mdpi.com
Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be
developed with high affinity and specificity to interact with any desired targets. They have …

Aptamers: A review of their chemical properties and modifications for therapeutic application

T Adachi, Y Nakamura - Molecules, 2019 - mdpi.com
Aptamers are short, single-stranded oligonucleotides that bind to specific target molecules.
The shape-forming feature of single-stranded oligonucleotides provides high affinity and …

Vimentin intermediate filaments as potential target for cancer treatment

K Strouhalova, M Přechová, A Gandalovičová… - Cancers, 2020 - mdpi.com
Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …

Vimentin diversity in health and disease

F Danielsson, MKK Peterson, H Caldeira Araújo… - Cells, 2018 - mdpi.com
Vimentin is a protein that has been linked to a large variety of pathophysiological conditions,
including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also …

Vimentin as a multifaceted player and potential therapeutic target in viral infections

I Ramos, K Stamatakis, CL Oeste… - International journal of …, 2020 - mdpi.com
Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal
functions, and therefore in basic cellular processes such as cell division and migration …

Aptamer therapeutics in cancer: current and future

Y Morita, M Leslie, H Kameyama, DE Volk, T Tanaka - Cancers, 2018 - mdpi.com
Aptamer-related technologies represent a revolutionary advancement in the capacity to
rapidly develop new classes of targeting ligands. Structurally distinct RNA and DNA …

[HTML][HTML] Nucleic acid aptamer-guided cancer therapeutics and diagnostics: the next generation of cancer medicine

D Xiang, S Shigdar, G Qiao, T Wang, AZ Kouzani… - Theranostics, 2015 - ncbi.nlm.nih.gov
Conventional anticancer therapies, such as chemo-and/or radio-therapy are often unable to
completely eradicate cancers due to abnormal tumor microenvironment, as well as …

DNA aptamers in the diagnosis and treatment of human diseases

Q Zhu, G Liu, M Kai - Molecules, 2015 - mdpi.com
Aptamers have a promising role in the field of life science and have been extensively
researched for application as analytical tools, therapeutic agents and as vehicles for …

Targeting vimentin: A multifaceted approach to combatting cancer metastasis and drug resistance

A Tabatabaee, B Nafari, A Farhang, A Hariri… - Cancer and Metastasis …, 2024 - Springer
This comprehensive review explores vimentin as a pivotal therapeutic target in cancer
treatment, with a primary focus on mitigating metastasis and overcoming drug resistance …

[HTML][HTML] Aptamers: A promising chemical antibody for cancer therapy

G Zhou, G Wilson, L Hebbard, W Duan, C Liddle… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aptamers, also known as chemical antibodies, are single-stranded nucleic acid
oligonucleotides which bind to their targets with high specificity and affinity. They are …