C− H Alkylation of Heterocycles via Light‐Mediated Palladium Catalysis

S Senapati, S Kumar Hota, L Kloene… - Angewandte …, 2024 - Wiley Online Library
Methods enabling direct C− H alkylation of heterocycles are of fundamental importance in
the late‐stage modification of natural products, bioactive molecules, and medicinally …

Photochemical reactions of biomass derived platform chemicals

N Hoffmann, MA Gomez Fernandez, A Desvals… - Frontiers in …, 2024 - frontiersin.org
Platform chemicals obtained from biomass will play an important role in chemical industry.
Already existing compounds or not yet established chemicals are produced from this …

Multidisciplinary Training for Fostering Next-Generation Medicinal Chemists

B Yu, X Lu, J Chang - Journal of Medicinal Chemistry, 2024 - ACS Publications
The field of medicinal chemistry has evolved and transformed significantly in both industrial
and academic sectors over the past decades, 1 seeing a paradigm shift from traditional …

Synthesis and modification of carbohydrates using metallaphotoredox catalysis and photoexcited-state transition metal catalysis

J Wang, F Zhou, Y Xu, L Zhang - Sustainable Chemistry and Pharmacy, 2025 - Elsevier
Transition metal catalysis has long been recognized as one of the most important tools for
the construction of carbon-carbon bond and carbon-heteroatom bonds in modern organic …

Structure-guided design and photochemical synthesis of new carbamo (dithioperoxo) thioates with improved potencies to SARS-CoV-2 3CLpro

DH Yin, J Xin, S Chen, SS Li, ZY Li, JX Meng… - Bioorganic & Medicinal …, 2024 - Elsevier
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has triggered a protracted
global pandemic from 2019 to 2022, and posed a significant threat to human health. One of …

Visible-light-promoted selenylation/cyclization of o-(1-alkynyl) benzoates to access seleno-substituted isocoumarins

ML Ren, XR Gong, YY Chen, YL Xu - Organic & Biomolecular …, 2024 - pubs.rsc.org
A simple and efficient method to access 4-selenyl-isocoumarin derivatives through visible-
light-promoted selenylation/cyclization of o-(1-alkynyl) benzoates has been developed. This …

Medicinal Chemistry Education: Emphasize Fundamentals and Skillfully Integrate Knowledge

S Du, X Hu, CW Lindsley, P Zhan - Journal of Medicinal Chemistry, 2024 - ACS Publications
Medicinal chemistry is an interdisciplinary field that aims to discover innovative drugs and
synthesize drug molecules at the intersection of chemistry and biology. In the field of …

Synthesis of Indole-Fused Benzodiazepine Derivatives by Photocatalyzed Cascade Reaction

T Oishi, T Uchikura, T Akiyama - Chemical Communications, 2025 - pubs.rsc.org
We report a cascade synthesis of indole-fused benzodiazepines by the photocatalyzed
addition of phenacyl radical, generated from α-acetoxy acetophenone, to 2-(3-methyl-1H …

A Photoactivatable Version of Ivabradine Enables Light-Induced Block of HCN Current In Vivo

A Porro, E Armano, F Brandalise… - Journal of Medicinal …, 2024 - ACS Publications
Therapeutic drugs, whose bioactivity is hindered by a photoremovable cage, offer the
advantage of spatiotemporal confinement of their action to the target diseased tissue with …

A Metal‐Free Photochemical Atom Transfer Radical Addition of CBr4 onto Alkenes as a Key Step for Their Conversion to Propargylamines

II Kontara, VA Panagiotari… - European Journal of …, 2024 - Wiley Online Library
Α green and sustainable metal‐free photochemical protocol for the atom transfer radical
addition (ATRA) of carbon tetrabromide onto alkenes was developed. Phenylglyoxylic acid …