During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the developing nervous system …

Unraveling the molecular mechanisms governing long-term synaptic plasticity is a key to
understanding how the brain stores information in neural circuits and adapts to a changing …

Neurotrophins are essential for multiple aspects of neuronal development and function.
Especially BDNF (brain-derived-neurotrophic-factor) has been shown to play an important …

Cyclin-dependent kinase 5 (Cdk5) is a multifaceted serine/threonine kinase protein with
important roles in the nervous system. Two related proteins, p35 and p39, activate Cdk5 …

In neurons, most microtubules are not associated with a central microtubule-organizing
center (MTOC), and therefore, both the minus and plus-ends of these noncentrosomal …

Brain‐derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic
and axonal growth during development and maintenance of the mature nervous system; …

Since the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of
the Cdk family almost 20 years ago, deregulation of Cdk5 activity has been linked to an …

Dendritic spines are specialized structures on neuronal processes where the majority of
excitatory synapses are localized. Spines are highly dynamic, and their stabilization and …

The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor TrkB participate
in diverse neuronal functions, including activity-dependent synaptic plasticity that is crucial …

The proline-directed serine threonine kinase, Cdk5, is an unusual molecule that belongs to
the well-known large family of proteins, cyclin-dependent kinases (Cdks). While it has …