I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Background Chronic rhinosinusitis with nasal polyposis (CRSwNP) is an inflammatory
condition of the upper airways. Optimal management is unclear. Objective We compared the …

Contributing Authors Isam Alobid, MD, PhD1, Nithin D. Adappa, MD2, Henry P. Barham,
MD3, Thiago Bezerra, MD4, Nadieska Caballero, MD5, Eugene G. Chang, MD6, Gaurav …

1.1. Summary The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the
update of similar evidence based position papers published in 2005 and 2007 and 2012 (1 …

Systemic type 2 inflammation encompassing T helper 2 (TH2)-type responses is emerging
as a unifying feature of both classically defined allergic diseases, such as asthma, and a …

The methodology for EPOS2012 has been the same as for the other two productions.
Leaders in the field were invited to critically appraise the literature and write a report on a …

Background The literature regarding clinical olfaction, olfactory loss, and olfactory
dysfunction has expanded rapidly over the past two decades, with an exponential rise in the …

This systematic review evaluates the efficacy and safety of biologicals for chronic
rhinosinusitis with nasal polyps (CRSwNP) compared with the standard of care. PubMed …

Chronic rhinosinusitis (CRS) affects more than 10% of the population in the United States
and Europe. Recent findings point to a considerable variation of inflammatory subtypes in …

With the increasing recognition of the role of type 2 immune responses in chronic
rhinosinusitis, its severity, recurrence, and comorbidities, several biologics targeting IL-4, IL …