BACKGROUND: Central mechanisms have been proposed to explain the prolongation of
effect reported with the off-label use of dexmedetomidine as an adjuvant in local anesthetic …

Purpose To compare the effects of dexmedetomidine (Dex) and fentanyl as adjuvants to
local anesthetics in spinal anesthesia. Methods Two researchers independently searched …

Although beneficial in acute and chronic pain management, the use of local anaesthetics is
limited by its duration of action and the dose dependent adverse effects on the cardiac and …

Purpose To assess the effects of dexmedetomidine on the duration of sensory and motor
block, postoperative analgesia, hypotension, bradycardia, and side effects in patients …

The alpha-2 agonist dexmedetomidine is being increasingly used for sedation and as an
adjunctive agent during general and regional anesthesia. It is used in a number of …

Background The surgical stress response plays an important role on the pathogenesis of
perioperative cardiac complications. Alpha‐2 adrenergic agonists attenuate this response …

Dexmedetomidine (DEX), a highly selective α 2-adrenergic receptor agonist, is the newest
agent introduced for sedation in intensive care unit (ICU). The sedation strategy for critically …

Aims: Intravenous (IV) dexmedetomidine with excellent sedative properties has been shown
to reduce analgesic requirements during general anaesthesia. A study was conducted to …

Purpose: Postoperative nausea and vomiting (PONV) is a frequent complication in
postoperative period. The aim of the current meta-analysis was to assess the efficacy of …

Background and Objectives Intravenous (IV) dexmedetomidine (DEX) is reported to prolong
the analgesic duration after single-shot interscalene brachial plexus block (ISBPB) …