The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …

Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Cutaneous and visceral leishmaniasis are amongst the most devastating infectious diseases
of our time, affecting millions of people worldwide. The treatment of these serious diseases …

Highlights•Leishmaniasis remains a neglected tropical disease, with a high unmet medical
need.•Therapeutic efficacy varies depending on the species of Leishmania parasite.•Leads …

Leishmaniasis is a neglected infectious disease caused by several different species of
protozoan parasites of the genus Leishmania. Current strategies to control this disease are …

Advocacy for better drugs and access to treatment has boosted the interest in drug discovery
and development for Chagas disease, a chronic infection caused by the genetically …

Background: Neglected tropical diseases (NTDs) are closely related to poverty and affect
over a billion people in developing countries. The unmet treatment needs cause high …

The increase of many deadly diseases like infections by multidrug-resistant bacteria implies
re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and …

Leishmaniasis is an infectious parasitic disease that is caused by protozoa of the genus
Leishmania, a member of the Trypanosomatidae family. Leishmaniasis is classified by the …

Tritryps diseases are devastating parasitic neglected infections caused by Leishmania spp.,
Trypanosoma cruzi and Trypanosoma brucei subspecies. Together, these parasites affect …