Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from …

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs), isolated from
discarded extra-embryonic tissue after birth, are promising candidate source of …

The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …

Disturbance of endoplasmic reticulum (ER) proteostasis is a common feature of amyotrophic
lateral sclerosis (ALS). Protein disulfide isomerases (PDI s) are ER foldases identified as …

Stem cells are a versatile source for cell therapy. Their use is particularly significant for the
treatment of neurological disorders for which no definitive conventional medical treatment is …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder resulting in
a lethal outcome. We studied changes in ventral horn perineuronal nets (PNNs) of …

Introduction: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of cortical,
brainstem, and spinal motor neurons; it causes progressive muscle weakness and atrophy …

Ex vivo gene therapy involves the genetic modification of cells outside of the body to
produce therapeutic factors and their subsequent transplantation back into patients. Various …

Neurodegenerative diseases are caused by a loss of neurons within the peripheral or
central nervous system. Inadequate repairability in the central nervous system and failure of …

Amyotrophic lateral sclerosis (ALS) is a lethal disease involving the loss of motor neurons.
Although the mechanisms responsible for motor neuron degeneration in ALS remain …