[HTML][HTML] Lipid systems for the delivery of amphotericin B in antifungal therapy

C Faustino, L Pinheiro - Pharmaceutics, 2020 - mdpi.com
Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty
years, remains the gold standard in the treatment of life-threatening invasive fungal …

Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery

L Huang, J Yang, T Wang, J Gao, D Xu - Journal of Nanobiotechnology, 2022 - Springer
A widely established prodrug strategy can effectively optimize the unappealing properties of
therapeutic agents in cancer treatment. Among them, lipidic prodrugs extremely uplift the …

Treatment of H. pylori infection and gastric ulcer: Need for novel Pharmaceutical formulation

A Gupta, S Shetty, S Mutalik, K Nandakumar… - Heliyon, 2023 - cell.com
Peptic ulcer disease (PUD) is one of the most prevalent gastro intestinal disorder which
often leads to painful sores in the stomach lining and intestinal bleeding. Untreated …

Exploring the permeability of Amphotericin B trough serum albumin dispersions and lipid nanocarriers for oral delivery

HR Marcelino, A Solgadi, M Chéron… - International Journal of …, 2023 - Elsevier
Amphotericin B (AmB) is a potent polyenic antifungal agent with leishmanicidal activity. Due
to its low solubility and permeability in the gastrointestinal tract, AmB is usually administered …

Potential lipid-based strategies of amphotericin B designed for oral administration in clinical application

X Zhong, J Yang, H Liu, Z Yang, P Luo - Drug Delivery, 2023 - Taylor & Francis
Amphotericin B (AmB) is regarded as a first-line therapy against life-threatening invasive
fungal infections. Due to its poor oral bioavailability, AmB is restricted to intravenous …

Design of double functionalized carbon nanotube for amphotericin B and genetic material delivery

S Yazdani, M Mozaffarian, G Pazuki, N Hadidi… - Scientific Reports, 2022 - nature.com
In the present work, single wall carbon nanotubes (SWCNT) were successively
functionalized with phospholipid DSPE-PEG carboxylic acid, and then, with ethylenediamine …

Recuperating biopharmaceutical aspects of amphotericin B and paromomycin using a chitosan functionalized nanocarrier via oral route for enhanced anti-leishmanial …

S Parvez, G Yadagiri, A Karole, OP Singh… - Frontiers in cellular …, 2020 - frontiersin.org
The design and development of new pharmaceutical formulations for the existing anti-
leishmanial is a new strategic alternate to improve efficacy and safety rather than new drug …

Review of novel oral amphotericin B formulations for the treatment of parasitic infections

E Wasan, T Mandava, P Crespo-Moran, A Nagy… - Pharmaceutics, 2022 - mdpi.com
Amphotericin B (AmpB) is a polyene macrolide antibiotic used in the treatment of blood-
borne parasitic and fungal infections. However, its use, particularly in the developing world …

Exploring the promising potential of high permeation vesicle-mediated localized transdermal delivery of docetaxel in breast cancer to overcome the limitations of …

M Bathara, T Date, D Chaudhari, R Ghadi… - Molecular …, 2020 - ACS Publications
The currently available systemic chemotherapy for treating breast cancer often results in
serious systemic side effects and compromises patient compliance. The distinct anatomical …

Progress in antileishmanial drugs: Mechanisms, challenges, and prospects

H Zhang, R Yan, Y Liu, M Yu, Z He, J Xiao… - PLOS Neglected …, 2025 - journals.plos.org
Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, continues to
pose global health challenges. Current treatments face issues like resistance, safety …