Viral modulation of lipid rafts and their potential as putative antiviral targets
Lipid rafts are ubiquitous in cells. They are identified as cholesterol and glycosphingolipid
enriched microdomains on cellular membranes. They serve as platforms for cellular …
enriched microdomains on cellular membranes. They serve as platforms for cellular …
CCR5 Gene Disruption via Lentiviral Vectors Expressing Cas9 and Single Guided RNA Renders Cells Resistant to HIV-1 Infection
CCR5, a coreceptor for HIV-1 entry, is a major target for drug and genetic intervention
against HIV-1. Genetic intervention strategies have knocked down CCR5 expression levels …
against HIV-1. Genetic intervention strategies have knocked down CCR5 expression levels …
[HTML][HTML] Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice
The last decade has led to a significant advance in our knowledge of HIV-1 latency and
immunity. However, we are still not close to finding a cure for HIV-1. Although combination …
immunity. However, we are still not close to finding a cure for HIV-1. Although combination …
Cell membrane-anchored anti-HIV single-chain antibodies and bifunctional inhibitors targeting the gp41 fusion protein: new strategies for HIV gene therapy
Y Chen, H Jin, X Tang, L Li, X Geng, Y Zhu… - Emerging Microbes & …, 2022 - Taylor & Francis
Emerging studies indicate that infusion of HIV-resistant cells could be an effective strategy to
achieve a sterilizing or functional cure. We recently reported that …
achieve a sterilizing or functional cure. We recently reported that …
A membrane-anchored short-peptide fusion inhibitor fully protects target cells from infections of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian …
X Tang, H Jin, Y Chen, L Li, Y Zhu, H Chong… - Journal of …, 2019 - Am Soc Microbiol
Emerging studies demonstrate that the antiviral activity of viral fusion inhibitor peptides can
be dramatically improved when being chemically or genetically anchored to the cell …
be dramatically improved when being chemically or genetically anchored to the cell …
Engineered CD4 T cells expressing a membrane anchored viral inhibitor restrict HIV-1 through cis and trans mechanisms
HIV-1 infection of target cells can occur through either cell-free virions or cell-cell
transmission in a virological synapse, with the latter mechanism of infection reported to be …
transmission in a virological synapse, with the latter mechanism of infection reported to be …
Animal models and therapeutic molecules
The invention discloses methods for the generation of chimaeric human—non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
Animal models and therapeutic molecules
The invention discloses methods for the generation of chimaeric human non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
Animal models and therapeutic molecules
The invention discloses methods for the generation of chimaeric human-non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
Animal models and therapeutic molecules
The invention discloses methods for the generation of chimaeric human-non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …