The virus interacts with its hosts by developing protein-protein interactions. Most viruses
employ protein interactions to imitate the host protein: A viral protein with the same amino …

Newly emerged SARS-CoV-2 is the cause of an ongoing global pandemic leading to severe
respiratory disease in humans. SARS-CoV-2 targets epithelial cells in the respiratory tract …

The filovirus VP40 protein directs virion egress, which is regulated either positively or
negatively by select VP40–host interactions. We demonstrate that host BAG3 and HSP70 …

Filovirus-host interactions play important roles in all stages of the virus lifecycle. Here, we
identify LATS1/2 kinases and YAP, key components of the Hippo pathway, as critical …

Like most enveloped viruses, HIV must acquire a lipid membrane as it assembles and buds
through the plasma membrane of infected cells to spread infection. Several sets of host cell …

Marburg virus (MARV) VP40 protein (mVP40) directs egress and spread of MARV, in part, by
recruiting specific host WW domain-containing proteins via its conserved PPxY late (L) …

The Ebola virus (EBOV) VP40 matrix protein (eVP40) orchestrates assembly and budding of
virions in part by hijacking select WW-domain–bearing host proteins via its PPxY late (L) …

Ebola virus (EBOV) and Marburg virus (MARV) continue to emerge and cause severe
hemorrhagic disease in humans. A comprehensive understanding of the filovirus-host …

Filoviruses produce viral particles with characteristic filamentous morphology. The major
viral matrix protein, VP40, is trafficked to the plasma membrane and promotes viral particle …

Filoviridae family members Ebola virus (EBOV) and Marburg virus (MARV) and Arenaviridae
family member Lassa virus (LASV) are emerging pathogens that can cause hemorrhagic …