The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Chromatin remodellers are specialized multi-protein machines that enable access to
nucleosomal DNA by altering the structure, composition and positioning of nucleosomes. All …

Near the 5′ end of most eukaryotic genes, nucleosomes form highly regular arrays that
begin at canonical distances from the transcriptional start site. Determinants of this and other …

Precise nucleosome organization at eukaryotic promoters is thought to be generated by
multiple chromatin remodeler (CR) enzymes and to affect transcription initiation. Using an …

Transcriptional repression of methylated genes can be mediated by the methyl-CpG binding
protein MeCP2. Here we show that human Brahma (Brm), a catalytic component of the …

Chromatin remodelers are ATP-hydrolyzing machines specialized to restructure, mobilize or
eject nucleosomes, allowing regulated exposure of DNA in chromatin. Recently, remodelers …

Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …

As primary carriers of epigenetic information and gatekeepers of genomic DNA,
nucleosomes are essential for proper growth and development of all eukaryotic cells …

Chromatin remodeling motors play essential roles in all DNA-based processes. These
motors catalyze diverse outcomes ranging from sliding the smallest units of chromatin …