The NFAT family of transcription factors encompasses five proteins evolutionarily related to
the Rel/NFκB family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family …

The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …

Recent technological advances have enabled DNA methylation to be assayed at single-cell
resolution. However, current protocols are limited by incomplete CpG coverage and hence …

Epithelial-to-mesenchymal transition (EMT) is fundamental to both embryogenesis and
tumor metastasis. The Notch intercellular signaling pathway regulates cell fate determination …

The zinc finger transcription factor GATA4 has been implicated in heart development based
on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the …

Previous studies have suggested that the GATA4 transcription factor plays an important role
in regulating mammalian cardiac development. In the studies described in this report we …

Six GATA transcription factors have been identified in vertebrates, each of which contains a
highly conserved DNA binding domain consisting of two zinc fingers of the motif Cys-X2-Cys …

GATA6 belongs to a family of zinc finger transcription factors that play important roles in
transducing nuclear events that regulate cellular differentiation and embryonic …

The tissue‐restricted GATA‐4 transcription factor and Nkx2‐5 homeodomain protein are two
early markers of precardiac cells. Both are essential for heart formation, but neither can …