Inflammation is a defensive reaction for external stimuli to the human body and generally
accompanied by immune responses, which is associated with multiple diseases such as …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Pancreatic cancer is a highly aggressive cancer, and is primarily treated with gemcitabine,
with increasing resistance. SIRT6 as a member of sirtuin family plays important roles in …

Background & Aims As a nicotinamide adenine dinucleotide-dependent deacetylase and a
key epigenetic regulator, sirtuin 6 (SIRT6) has been implicated in the regulation of …

The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-
dependent deacylase and mono-ADP-ribosyltransferase. Sirtuins display distinct subcellular …

Sirt6 is one of the sirtuin family members, a kind of NAD+-dependent histone deacetylase
and ADP-ribose transferase enzyme. It has an important role in physiological and …

Alcoholic liver disease (ALD) is a serious worldwide health problem. Ginsenoside Rc is a
major active ingredient isolated from Panax ginseng, whose pharmacological effects …

Pyroptosis is identified as a pro-inflammatory programmed cell death, mediated by
gasdermins (GSDMs) family of proteins accompanied by pro-inflammatory signals release …

The morbidity and mortality of diabetes have increased dramatically in recent decades.
Novel strategies for treating diabetes and its complications with minimal side effects are in …