Background. Next‐generation sequencing methods have been developed and proposed to
investigate any query in genomics or clinical activity involving DNA. Technical advancement …

The combination of next-generation sequencing and advanced computational data analysis
approaches has revolutionized our understanding of the genomic underpinnings of cancer …

Over the past 15 years, rapid progress has been made in developmental therapeutics,
especially regarding the use of matched targeted therapies against specific oncogenic …

Purpose: Not all patients with metastatic castration-resistant prostate cancer (mCRPC) have
sufficient tumor tissue available for multigene molecular testing. Furthermore, samples may …

Application of next-generation sequencing (NGS) technology to routine clinical practice has
enabled characterization of personalized cancer genomes to identify patients likely to have …

Objective Low-grade serous carcinoma (LGSOC) is a rare epithelial ovarian/peritoneal
cancer characterized by younger age at diagnosis, relative chemoresistance, prolonged …

Since the establishment of the Sanger sequencing method, scientists around the world
focused their efforts to progress in the field to produce the utmost technology. The …

Simple Summary Due to the increase of molecular biomarkers to be characterized to tailor
therapeutic strategies for non-squamous non-small cell lung carcinoma (NS-NSCLC), it is …

Next-generation sequencing (NGS) for molecular diagnostics allows simultaneous testing of
activating oncogenes and tumor suppressor mutations in multiple signal pathways …

Context.—In an era in which testing of patient tumor material for molecular and other
ancillary studies is of increasing clinical importance for selection of therapy, the ability to test …