Introduction Brazilin is a promising natural red dye, extracted from the wood of Caesalpinia
sappan L. It exhibits several pharmacological activities including anti-inflammatory …

Caesalpinia sappan and Haematoxylum brasiletto belong to the Fabaceae family,
predominantly distributed in Southeast Asia and America. The isoflavonoid brazilin has …

Abstract Vernonia amygdalina Delile (Asteraceae) is used in traditional medicine to treat
diabetes mellitus, and some research provides its activity to treat breast cancer. The aim of …

Background Cisplatin is one of the first-line drugs for urothelial bladder cancer (UBC)
treatment. However, its considerable side effects and the emergence of drug resistance are …

Purpose: Breast cancer cells with overexpression of HER2 are known to be more
aggressive, invasive, and resistant to chemotherapeutic agent. Brazilin, the major compound …

Protein disulfide isomerase (PDI) is responsible for nascent protein folding in the
endoplasmic reticulum (ER) and is critical for glioblastoma survival. To improve the potency …

Objective: The present research aims to report cytotoxic and antimigratory activities of the
oxidized form of brazilin, ie, brazilein, and the effects of the combination of brazilein …

Background Triple-negative breast cancer (TNBC) is a type of breast cancer whose
treatment is significantly more complicated than that for other forms of breast cancer …

Endometriosis is a common gynecological disease defined as the growth of endometrial
tissues outside the uterus. Although the mechanism underlying the progression of …

Cancer is a global health concern and one of the main causes of disease-related death.
Even with considerable progress in investigations on cancer therapy, effective anti-cancer …