Growth mechanisms of amorphous nanoparticles in solution and during heat drying
The purpose of this study was twofold: to identify the growth mechanisms of amorphous
nanoparticles in solution and during the drying process at high temperatures, and to guide …
nanoparticles in solution and during the drying process at high temperatures, and to guide …
Design of Redispersible High-Drug-Load Amorphous Formulations: Impact of Ionic vs Nonionic Surfactants on Processing and Performance
M Yu, HS Oberoi, HS Purohit, CA Fowler… - Molecular …, 2023 - ACS Publications
Amorphous solid dispersions (ASDs) are an enabling formulation approach used to
enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich …
enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich …
Generality of Enhancing the Dissolution Rates of Free Acid Amorphous Solid Dispersions by the Incorporation of Sodium Hydroxide
HJ Zhang, CW Chiang… - Molecular …, 2024 - ACS Publications
The incorporation of a counterion into an amorphous solid dispersion (ASD) has been
proven to be an attractive strategy to improve the drug dissolution rate. In this work, the …
proven to be an attractive strategy to improve the drug dissolution rate. In this work, the …
Scale-up and clinical bioavailability assessment of a 45% drug loaded amorphous nanoparticle formulation of a BCS IV compound for oral delivery
Abstract A 45% drug loaded (DL) amorphous nanoparticle (ANP) formulation for a BCS IV
drug demonstrated promising pharmacokinetics in dogs (Purohit, et al., J. Pharm. Sci. 2023 …
drug demonstrated promising pharmacokinetics in dogs (Purohit, et al., J. Pharm. Sci. 2023 …
Comparisons of the bioavailability of icariin, icariside II, and epimedin C in rats after oral administration of total flavonoids of Epimedium brevicornu Maxim. and its …
Z Ding, X Chen, D Tang, T Ye, J Yang, Y Yu… - Journal of Pharmaceutical …, 2024 - Elsevier
The low bioavailability of insoluble flavonoids in the total flavonoids of Epimedium
brevicornu Maxim.(TFE) severely hindered its clinical efficacy exertion. This research …
brevicornu Maxim.(TFE) severely hindered its clinical efficacy exertion. This research …