Remyelination involves reinvesting demyelinated axons with new myelin sheaths. In stark
contrast to the situation that follows loss of neurons or axonal damage, remyelination in the …

Cell transplantation therapies have become a major focus in pre-clinical research as a
promising strategy for the treatment of spinal cord injury (SCI). In this article, we …

Rho kinases (ROCKs), the first Rho effectors to be described, are serine/threonine kinases
that are important in fundamental processes of cell migration, cell proliferation and cell …

The Schwann cell plays a vital role in maintaining the peripheral nervous system (PNS).
Schwann cells are derived from neural crest cells, and come in two types either myelinating …

OBJECTIVE: To provide a comprehensive review of the treatment trials in the field of spinal
cord injury, emphasizing what has been learned about the effectiveness of the agents and …

There is a pressing need for treatments for neurodegenerative diseases. Hopes have been
raised by the prospect of neural stem cell therapy; however, despite intense research …

Although neural stem cells hold considerable promise for treatment of the injured or
degenerating nervous system, their current human sources are embryonic stem cells and …

Bone marrow contains a population of pluripotent cells that can differentiate into a variety of
cell lineages, including neural cells. When injected directly into the demyelinated spinal cord …

A principal objective of spinal cord injury (SCI) research is the restoration of axonal
connectivity to denervated targets. We tested the hypothesis that chemotropic mechanisms …

During the last few years, the therapeutic use of stem and progenitor cells as a substitute for
malfunctioning endogenous cell populations has received considerable attention. Unlike …