Adult-onset neurodegenerative disorders are disabling and often fatal diseases of the
nervous system whose underlying mechanisms of cell death remain unknown. Defects in …

Mitochondria are increasingly recognized as central players in the life and death of cells and
especially of neurons. The energy-dependence of retinal ganglion cells (RGC) and their …

The integrity of mitochondrial function is fundamental to cell life. It follows that disturbances
of mitochondrial function will lead to disruption of cell function, expressed as disease or …

Energy use, mainly to reverse ion movements in neurons, is a fundamental constraint on
brain information processing. Trafficking of mitochondria to locations in neurons where there …

Neurons and glia maintain central nervous system (CNS) homeostasis through diverse
mechanisms of intra-and intercellular signaling. Some of these interactions include the …

Organelle transport is vital for the development and maintenance of axons, in which the
distances between sites of organelle biogenesis, function, and recycling or degradation can …

To address questions about mechanisms of filament-based organelle transport, a system
was developed to image and track mitochondria in an intact Drosophila nervous system …

Mitochondria are highly dynamic organelles with complex structural features which play
several important cellular functions, such as the production of energy by oxidative …

Mitochondria are distributed within cells to match local energy demands. We report that the
microtubule-dependent transport of mitochondria depends on the ability of milton to act as …

Proper distribution of mitochondria within axons and at synapses is critical for neuronal
function. While one-third of axonal mitochondria are mobile, a large proportion remains in a …