Targeting NEK2 as a promising therapeutic approach for cancer treatment

Y Fang, X Zhang - Cell Cycle, 2016 - Taylor & Francis
ABSTRACT Never in Mitosis (NIMA) Related Kinase 2 (NEK2) plays a key role in regulating
mitotic processes, including centrosome duplication and separation, microtubule …

Menage a trois: an evolutionary interplay between human papillomavirus, a tumor, and a woman

N Shulzhenko, H Lyng, GF Sanson, A Morgun - Trends in microbiology, 2014 - cell.com
Cervical cancer is the third most common cancer in women with human papillomavirus
(HPV) being a key etiologic factor of this devastating disease. In this article, we describe …

[HTML][HTML] NEK2 promotes proliferation, migration and tumor growth of gastric cancer cells via regulating KDM5B/H3K4me3

Y Li, L Chen, L Feng, M Zhu, Q Shen… - American Journal of …, 2019 - ncbi.nlm.nih.gov
The mechanisms of how Never in Mitosis (NIMA) Related Kinase 2 (NEK2) coordinates
altered signaling to malignant gastric cancer (GC) transformation remain unclear …

[HTML][HTML] NEK2 inactivates the Hippo pathway to advance the proliferation of cervical cancer cells by cooperating with STRIPAK complexes

YR Zhang, PS Zheng - Cancer Letters, 2022 - Elsevier
The never in mitosis gene A (NIMA)-related kinase 2 (NEK2) protein has been reported to be
an oncoprotein that plays different oncogenic roles in multiple cancers. Here, we confirmed …

Upregulation of NEK2 is associated with drug resistance in ovarian cancer

X Liu, Y Gao, Y Lu, J Zhang, L Li… - Oncology …, 2014 - spandidos-publications.com
NEK2 [NIMA (never in mitosis gene A)-related expressed kinase 2] is associated with
various biological behaviors in the development of cancer, while research concerning its …

Human bone marrow mesenchymal stem cell‐derived extracellular vesicles impede the progression of cervical cancer via the miR‐144‐3p/CEP55 pathway

Q Meng, B Zhang, Y Zhang, S Wang… - Journal of cellular and …, 2021 - Wiley Online Library
Cervical cancer is the most common gynaecological malignancy, with a high incidence rate
and mortality rate in middle‐aged women. Human bone marrow mesenchymal stem cells …

Overexpression of NIMA-related kinase 2 is associated with progression and poor prognosis of prostate cancer

YR Zeng, ZD Han, C Wang, C Cai, YQ Huang, HW Luo… - BMC urology, 2015 - Springer
Background The NIMA-related kinase 2 (NEK2) is a serine/threonine kinase that is involved
in regulation of centrosome duplication and spindle assembly during mitosis. Dysregulation …

Cancer/testis antigens:“smart” biomarkers for diagnosis and prognosis of prostate and other cancers

P Kulkarni, VN Uversky - International journal of molecular sciences, 2017 - mdpi.com
A clinical dilemma in the management of prostate cancer (PCa) is to distinguish men with
aggressive disease who need definitive treatment from men who may not require immediate …

lncRNA SNHG1 promotes progression of cervical cancer through miR-195/NEK2 axis

YY Ji, M Meng, Y Miao - Cancer Management and Research, 2020 - Taylor & Francis
Objective Cervical cancer is a common gynecologic cancer, and no study has been reported
on the way through which lncRNA SNHG1, miR-195 and NEK2 jointly affect cervical cancer …

Signaling pathways involved in 5-FU drug resistance in cancer

F Danesh Pouya, Y Rasmi, M Nemati - Cancer Investigation, 2022 - Taylor & Francis
Anti-metabolite drugs prevent the synthesis of essential cell growth compounds. 5-
fluorouracil is used as an anti-metabolic drug in various cancers in the first stage of …