Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis

R Lalor, K Cwiklinski, NED Calvani, A Dorey, S Hamon… - Virulence, 2021 - Taylor & Francis
Fasciolosis caused by the liver flukes Fasciola hepatica and Fasciola gigantica is one of the
most important neglected parasitic diseases of humans and animals. The ability of the …

The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola

K Cwiklinski, S Donnelly, O Drysdale, H Jewhurst… - Advances in …, 2019 - Elsevier
Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of
livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human …

Eosinophils and macrophages within the Th2-induced granuloma: balancing killing and healing in a tight space

A Ariyaratne, CAM Finney - Infection and Immunity, 2019 - Am Soc Microbiol
Granuloma formation is a key host immune response generated to confine invading
pathogens and limit extensive host damage. It consists of an accumulation of host immune …

[HTML][HTML] Insights into Fasciola hepatica juveniles: crossing the fasciolosis rubicon

J González-Miguel, D Becerro-Recio… - Trends in …, 2021 - cell.com
Unraveling the molecular interactions governing the first contact between parasite and host
tissues is of paramount importance to the development of effective control strategies against …

[HTML][HTML] Fasciolosis—an increasing challenge in the sheep industry

S Stuen, C Ersdal - Animals, 2022 - mdpi.com
Simple Summary Fasciolosis caused by Fasciola hepatica is a serious disease and a huge
challenge in the sheep industry. The disease has several clinical manifestations including …

Advances in Fasciola hepatica research using 'omics' technologies

K Cwiklinski, JP Dalton - International journal for parasitology, 2018 - Elsevier
The liver fluke Fasciola hepatica is an economically important pathogen of livestock
worldwide, as well as being an important neglected zoonosis. Parasite control is reliant on …

[HTML][HTML] Fasciola hepatica hijacks host macrophage miRNA machinery to modulate early innate immune responses

N Tran, A Ricafrente, J To, M Lund, TM Marques… - Scientific reports, 2021 - nature.com
Fasciola hepatica, a global worm parasite of humans and their livestock, regulates host
innate immune responses within hours of infection. Host macrophages, essential to the first …

Host–parasite interactions mediated by cross-species microRNAs

X He, W Pan - Trends in parasitology, 2022 - cell.com
Parasitic diseases are still the common diseases that seriously threaten human health and
life, and a better understanding of host–parasite interactions is the key to effectively …

[HTML][HTML] Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases

C De Marco Verissimo, HL Jewhurst… - PLoS Neglected …, 2020 - journals.plos.org
Serine protease inhibitors (serpins) regulate proteolytic events within diverse biological
processes, including digestion, coagulation, inflammation and immune responses. The …

An Update on the Pathogenesis of Fascioliasis: What Do We Know?

MB Tanabe, MA Caravedo… - … and Reports in …, 2024 - Taylor & Francis
Fasciola hepatica is a trematode parasite distributed worldwide. It is known to cause disease
in mammals, producing significant economic loses to livestock industry and burden to …