Sleep deprivation and neurological disorders
Sleep plays an important role in maintaining neuronal circuitry, signalling and helps
maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian …
maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian …
Synaptic memory and CaMKII
RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …
were discovered within a decade of each other and have been inextricably intertwined ever …
Synaptic memory requires CaMKII
Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and
memory. While the mechanisms underlying the induction of LTP ('learning') are well …
memory. While the mechanisms underlying the induction of LTP ('learning') are well …
[HTML][HTML] CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin
Summary The Ca 2+/calmodulin-dependent protein kinase II (CaMKII) is critically required
for the synaptic recruitment of AMPA-type glutamate receptors (AMPARs) during both …
for the synaptic recruitment of AMPA-type glutamate receptors (AMPARs) during both …
Amyloid β induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation
HY Wu, E Hudry, T Hashimoto… - Journal of …, 2010 - Soc Neuroscience
Amyloid β (Aβ)-containing plaques are surrounded by dystrophic neurites in the Alzheimer's
disease (AD) brain, but whether and how plaques induce these neuritic abnormalities …
disease (AD) brain, but whether and how plaques induce these neuritic abnormalities …
Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats
Y Oomura, N Hori, T Shiraishi, K Fukunaga, H Takeda… - Peptides, 2006 - Elsevier
Leptin, an adipocytokine encoded by an obesity gene and expressed in adipose tissue,
affects feeding behavior, thermogenesis, and neuroendocrine status via leptin receptors …
affects feeding behavior, thermogenesis, and neuroendocrine status via leptin receptors …
Calcineurin: from structure to function
J Aramburu, A Rao, CB Klee - Current topics in cellular regulation, 2001 - Elsevier
Publisher Summary The use of the calcineurin inhibitors—namely, FK506 and CsA, together
with yeast genetics and the overexpression of calcineurin by transgenic mice, has …
with yeast genetics and the overexpression of calcineurin by transgenic mice, has …
Roles of serine/threonine phosphatases in hippocampel synaptic plasticity
DG Winder, JD Sweatt - Nature Reviews Neuroscience, 2001 - nature.com
The regulation of glutamate-mediated excitatory neurotransmission has a critical role in
many aspects of behaviour. Great effort has gone into understanding the signal transduction …
many aspects of behaviour. Great effort has gone into understanding the signal transduction …
Intermediate-and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition
G Taglialatela, D Hogan, WR Zhang… - Behavioural brain …, 2009 - Elsevier
The Tg2576 transgenic mouse is an extensively characterized animal model for Alzheimer's
disease (AD). Similar to AD, these mice suffer from progressive decline in several forms of …
disease (AD). Similar to AD, these mice suffer from progressive decline in several forms of …
Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin
DG Winder, IM Mansuy, M Osman, TM Moallem… - Cell, 1998 - cell.com
To investigate the role of phosphatases in synaptic plasticity using genetic approaches, we
generated transgenic mice that overexpress a truncated form of calcineurin under the control …
generated transgenic mice that overexpress a truncated form of calcineurin under the control …