Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

Anoikis is a programmed cell death induced upon cell detachment from extracellular matrix,
behaving as a critical mechanism in preventing adherent-independent cell growth and …

Abstract Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including
modulation of cellular responses involved in tumorigenesis. Genetic mutations and altered …

Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

The programmed cell death that occurs as part of normal mammalian development was first
observed nearly a century ago (Collin 1906). It has since been established that …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Anoikis is a programmed cell death occurring upon cell detachment from the correct
extracellular matrix, thus disrupting integrin ligation. It is a critical mechanism in preventing …

Caspases are a family of cysteine proteases that play important roles in regulating
apoptosis. A decade of research has generated a wealth of information on the signal …

Caspases play an essential role during apoptotic cell death. These enzymes define a new
class of cysteine proteases and comprise a multi-gene family with more than a dozen distinct …

Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …