Systemic sclerosis (SSc) is a chronic multi-system autoimmune disease associated with
disability and reduced quality of life. There is no effective treatment or cure to SSc, so it is …

Mesenchymal stromal/stem cells (MSC) are non-hematopoietic multipotent progenitor cells,
first described in bone marrow in the middle of last century. Since then, MSC have been the …

Pulmonary fibrosis is one of the important causes of morbidity and mortality in
fibroproliferative disorders such as systemic sclerosis (SSc) and idiopathic pulmonary …

The molecule serotonin (5-hydroxytryptamine or 5-HT) is involved in numerous biological
processes both inside and outside of the central nervous system. 5-HT signals through 5-HT …

Fibrotic autoimmune diseases are characterized by an inflammatory process in which
fibrogenic cytokines, such as TGFβ and IL6, have a major role. Interestingly, these cytokines …

Abstract Platelets serotonin (5-hydroxytrytamine, 5-HT) uptake and storage in dense
granules is tightly regulated by the serotonergic transport system in the blood. Several 5-HT …

OBJECTIVES: To investigate the prevalence and predictors of pulmonary hypertension (PH)
in patients with systemic lupus erythematosus (SLE) and to validate a diagnostic strategy …

Abstract Objective Systemic sclerosis (SSc) is an immune-mediated disorder characterized
by multiple organ fibrotic alterations and diffuse microangiopathy. The SSc can be …

Interstitial lung disease (ILD) is a frequent complication of inflammatory myopathies with
high rates of morbidity and mortality. Antibodies against aminoacyl-tRNA-synthetases are …

The etiology and pathogenesis of systemic sclerosis are still largely unknown, but a variety
of humoral and cellular autoimmune phenomena have been documented. In addition, the …