Roles of HLA-G in the maternal-fetal immune microenvironment
X Xu, Y Zhou, H Wei - Frontiers in immunology, 2020 - frontiersin.org
During pregnancy, the maternal uterus and fetus form a special microenvironment at the
maternal-fetal interface to support fetal development. Extravillous trophoblasts (EVTs) …
maternal-fetal interface to support fetal development. Extravillous trophoblasts (EVTs) …
HLA-G: at the interface of maternal–fetal tolerance
During pregnancy, semiallogeneic fetal extravillous trophoblasts (EVT) invade the uterine
mucosa without being rejected by the maternal immune system. Several mechanisms were …
mucosa without being rejected by the maternal immune system. Several mechanisms were …
Trained memory of human uterine NK cells enhances their function in subsequent pregnancies
M Gamliel, D Goldman-Wohl, B Isaacson, C Gur… - Immunity, 2018 - cell.com
Natural killer cells (NKs) are abundant in the human decidua, regulating trophoblast
invasion and angiogenesis. Several diseases of poor placental development are associated …
invasion and angiogenesis. Several diseases of poor placental development are associated …
HLA-G: an immune checkpoint molecule
ED Carosella, N Rouas-Freiss, D Tronik-Le Roux… - Advances in …, 2015 - Elsevier
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …
NK cell recognition
LL Lanier - Annu. Rev. Immunol., 2005 - annualreviews.org
NK CELL RECOGNITION | Annual Reviews Menu Publications AZ Journal Information About
Subscribe Give Personal Register/Sign-in 0 Cart Help Journal Information Author Resource …
Subscribe Give Personal Register/Sign-in 0 Cart Help Journal Information Author Resource …
Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
SE Hiby, JJ Walker, KM O'shaughnessy… - The Journal of …, 2004 - rupress.org
Preeclampsia is a serious complication of pregnancy in which the fetus receives an
inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the …
inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the …
Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential
LA Koopman, HD Kopcow, B Rybalov… - The Journal of …, 2003 - rupress.org
Natural killer cells constitute 50–90% of lymphocytes in human uterine decidua in early
pregnancy. Here, CD56bright uterine decidual NK (dNK) cells were compared with the …
pregnancy. Here, CD56bright uterine decidual NK (dNK) cells were compared with the …
Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association
The HLA-G gene displays several peculiarities that are distinct from those of classical HLA
class I genes. The unique structure of the HLA-G molecule permits a restricted peptide …
class I genes. The unique structure of the HLA-G molecule permits a restricted peptide …
HLA‐G and immune tolerance in pregnancy
JS Hunt, MG Petroff, RH McIntire, C Ober - The FASEB Journal, 2005 - Wiley Online Library
Multiple mechanisms underlie the surprising willingness of mothers to tolerate genetically
different fetal tissues during pregnancy. Chief among these is the choice of HLA‐G, a gene …
different fetal tissues during pregnancy. Chief among these is the choice of HLA‐G, a gene …
Human uterine leukocytes and pregnancy
A Trundley, A Moffett - Tissue antigens, 2004 - Wiley Online Library
In human pregnancy, the embryo implants into the specialized mucosal wall of the uterus
(decidua) and the placenta starts to form. Cells from the placenta (trophoblasts) invade into …
(decidua) and the placenta starts to form. Cells from the placenta (trophoblasts) invade into …