Abstract Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important
transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master …

Protein-protein interactions (PPIs) are central to a variety of biological processes, and their
dysfunction is implicated in the pathogenesis of a range of human diseases, including …

One of the main goals of modern synthesis is to develop distinct reaction pathways from
identical starting materials for the efficient synthesis of diverse compounds. Herein, we …

Histone lysine methylation is a post-translational modification that plays a key role in the
epigenetic regulation of a broad spectrum of biological processes. Moreover, the …

A Na2S2O8-initiated sulfonylation of pyridyl phosphonium salts with sulfinate salts in
aqueous media has been developed for facile access to 4-pyridyl sulfones. The reactions …

Mixed lineage leukemia (MLL) gene rearrangements are associated with acute leukemia.
The protein menin is regarded as a critical oncogenic cofactor of the resulting MLL fusion …

Introduction Chromosomal translocations involving the mixed-lineage leukemia (MLL,
KMT2A, MLL1) genes result in the production of MLL fusion proteins, which cause abnormal …

Simple Summary Epigenetic modifications can regulate gene expression by altering
chromatin structure. Since the beginning of comprehensive research into changes in gene …

Epigenetics has emerged as an extremely exciting fast-growing area of biomedical research
in post genome era. Epigenetic dysfunction is tightly related with various diseases such as …

Targeting the menin-MLL protein–protein interaction is being pursued as a new therapeutic
strategy for the treatment of acute leukemia carrying MLL-rearrangements (MLLr leukemia) …