Background Molecular diagnostics are considered the most promising route to achievement
of rapid, universal drug susceptibility testing for Mycobacterium tuberculosis complex …

Long diagnostic wait times hinder international efforts to address antibiotic resistance in M.
tuberculosis. Pathogen whole genome sequencing, coupled with statistical and machine …

Drug susceptibility testing of M. tuberculosis is rooted in a binary susceptible/resistant
paradigm. While there are considerable advantages in measuring the minimum inhibitory …

Neisseria gonorrhoeae is an urgent public health threat due to the emergence of antibiotic
resistance. As most isolates in the United States are susceptible to at least one antibiotic …

The advent of rapid whole-genome sequencing has created new opportunities for
computational prediction of antimicrobial resistance (AMR) phenotypes from genomic data …

Tuberculosis (TB) remains one of the most significant global health problems, posing a
significant challenge to public health systems worldwide. However, diagnosing drug …

The occurrence of multiple strains of a bacterial pathogen such as M. tuberculosis or C.
difficile within a single human host, referred to as a mixed infection, has important …

Group testing, the testing paradigm which combines multiple samples within a single test,
was introduced in 1943 by Robert Dorfman. Since its original proposal for syphilis …

Motivation: Drug resistance in Mycobacterium tuberculosis (MTB) is a growing threat to
human health worldwide. One way to mitigate the risk of drug resistance is to enable …

Drug resistance (DR) remains a global healthcare concern. In contrast to other human
bacterial pathogens, acquiring mutations in the genome is the main mechanism of drug …