4-Hydroxyphenylpyruvate dioxygenase (HPPD) plays a key role in tyrosine metabolism and
has been identified as a promising target for herbicide and drug discovery. The structures of …

Pellino1 (Peli1) is a highly conserved E3 Ub ligase that exerts its biological functions by
mediating target protein ubiquitination. Extensive evidence has demonstrated the crucial …

Ferroptosis is a cell death modality in which iron-dependent lipid peroxides accumulate on
cell membranes. Cysteine, a limiting substrate for the glutathione system that neutralizes …

High-potency 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors are usually featured
by time-dependent inhibition. However, the molecular mechanism underlying time …

Dietary protein intake modulates growth, reproduction, and longevity by stimulating amino
acid (AA)–sensing pathways. Essential AAs are often considered as limiting nutrients during …

Objective A ketogenic diet or mildly increased ketone body levels are beneficial for diabetic
kidney disease (DKD) patients. Our previous study has found that sodium-coupled …

Hereditary tyrosinemia type I (HT1) results from the loss of fumarylacetoacetate hydrolase
(FAH) activity and can lead to lethal liver injury (LLI). Therapeutic options for HT1 remain …

Congenital heart disease (CHD) is one of the most prevalent neonatal congenital
anomalies. To catalog the putative candidate CHD risk genes, we collected 16,349 variants …

Hepatocellular carcinoma (HCC) remains an incurable disease with a very poor clinical
outcome. The purpose of this article was to investigate whether the expression or …

Purpose Lower back pain (LBP), mainly caused by intervertebral disk (IVD) degeneration
(IDD), is widely prevalent worldwide and is a serious socioeconomic burden. Numerous …