Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have been the
mainstay of treatment for patients with advanced renal cell carcinoma (RCC). Despite its …

The fundamental novelty in the pathogenesis of renal cell carcinoma (RCC) was discovered
as a result of the recent identification of the role of long non-coding RNAs (lncRNAs). Here …

Purpose: A minority of patients currently respond to single-agent immune-checkpoint
blockade (ICB), and strategies to increase response rates are urgently needed. AXL is a …

Clear cell renal cell carcinoma (ccRCC) is characterized by accumulation of neutral lipids
and adipogenic transdifferentiation. We assessed adipokine expression in ccRCC and …

Background Nrf2 constitutes a therapeutic reference point for renal fibrosis and chronic
kidney diseases. Nrf2-related signaling pathways are recognized to temper endothelial-to …

Epithelial-to-mesenchymal transition (EMT) is a key biological process involved in a
multitude of developmental and pathological events. It is characterized by the progressive …

The aim of this study was to identify key genes associated with gliomas and glioblastoma
and to explore the related signaling pathways. Gene expression profiles of three glioma …

Down-regulation/mutation of AT-rich interactive domain 1A (ARID1A), a novel tumor
suppressor gene, has been reported in various cancers. Nevertheless, its role in renal cell …

Epithelial–mesenchymal transition (EMT), a reversible cellular program, is critically
important in tumor progression and is regulated by a family of transcription factors, induction …

microRNAs (miRNAs) are emerging as relevant molecules in cancer development and
progression. MiRNAs add a post-transcriptional level of control to the regulation of gene …