Interleukin (IL)-21 in inflammation and immunity during parasitic diseases

S Solaymani-Mohammadi, L Eckmann… - Frontiers in cellular and …, 2019 - frontiersin.org
Parasitic diseases cause significant morbidity and mortality in the developing and
underdeveloped countries. No efficacious vaccines are available against most parasitic …

A human antibody epitope map of the malaria vaccine antigen Pfs25

N Shukla, WK Tang, CH Coelho, CA Long, SA Healy… - npj Vaccines, 2023 - nature.com
Pfs25 is a leading antigen for a malaria transmission-blocking vaccine and shows moderate
transmission-blocking activity and induction of rapidly decreasing antibody titers in clinical …

Characterization of drug resistance and genetic diversity of Plasmodium falciparum parasites from Tripura, Northeast India

SJ Patgiri, K Sarma, N Sarmah, N Bhattacharyya… - Scientific Reports, 2019 - nature.com
Monitoring of anti-malarial drug resistance is vital in Northeast India as this region shares its
international border with Southeast Asia. Genetic diversity of Plasmodium parasites …

Genetic polymorphism of Plasmodium falciparum msp-1, msp-2 and glurp vaccine candidate genes in pre-artemisinin era clinical isolates from Lakhimpur district in …

V Sathishkumar, T Nirmolia… - Access …, 2022 - microbiologyresearch.org
Background. Northeast India shares its international border with Southeast Asia and has a
number of malaria endemic zones. Monitoring genetic diversity of malaria parasites is …

Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya

KO Ochwedo, SA Onyango, CJ Omondi, PW Orondo… - Plos one, 2022 - journals.plos.org
Background Leading transmission-blocking vaccine candidates such as Plasmodium
falciparum surface protein 25 (Pfs25 gene) may undergo antigenic alterations which may …

Exploring the room for repurposed hydroxychloroquine to impede COVID-19: toxicities and multipronged combination approaches with pharmaceutical insights

A Jain, SK Prajapati, M Tripathi… - Expert Review of …, 2021 - Taylor & Francis
ABSTRACT Introduction: SARS-CoV-2 has fatally affected the whole world with millions of
deaths. Amidst the dilemma of a breakthrough in vaccine development, hydroxychloroquine …

Global diversity of the gene encoding the Pfs25 protein—a Plasmodium falciparum transmission-blocking vaccine candidate

P Sookpongthai, K Utayopas, T Sitthiyotha… - Parasites & …, 2021 - Springer
Background Vaccines against the sexual stages of the malarial parasite Plasmodium
falciparum are indispensable for controlling malaria and abrogating the spread of drug …

Exploration of genetic diversity of Plasmodium vivax circumsporozoite protein (Pvcsp) and Plasmodium vivax sexual stage antigen (Pvs25) among North Indian …

H Kaur, R Sehgal, A Kumar, A Sehgal, PK Bharti… - Malaria journal, 2019 - Springer
Background Malaria is one of the important vector-borne diseases with high fatality rates in
tropical countries. The pattern of emergence and spread of novel antigenic variants, leading …

Temporal dynamics of Plasmodium falciparum population in Metehara, east-central Ethiopia

AG Reda, A Messele, H Mohammed, A Assefa… - Malaria Journal, 2022 - Springer
Background Plasmodium falciparum is the most serious, genetically most complex and
fastest-evolving malaria parasite. Information on genetic diversity of this parasite would …

Genetic characterization of Plasmodium vivax isolates from Pakistan using circumsporozoite protein (pvcsp) and merozoite surface protein-1 (pvmsp-1) genes as …

Z Bibi, A Fatima, R Rani, A Maqbool, S Khan, S Naz… - Malaria journal, 2021 - Springer
Background Plasmodium vivax contributes to over 70% malaria burden in Pakistan, but
limited data exists on various aspects including genetic diversity of the parasite as compared …